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Here are my Week 12 NFL Game Predictions, both straight-up and against the spread and my results from last week and the season.
You’ll also find an array of fantastic notes down below for Week 12 and the 2025 season courtesy of NFL Communications press releases.
There are 24 VFLs on 53-player rosters in the NFL. There are 2 on practice squads and 4 more on injured reserve, bringing the league total to 30 with NFL teams. Look for a VFL in the NFL, ex-Vol and local player update blog soon on this feed and website, 991TheSportsAnimal.com.
Vince’s Picks Results
Week 12: 9-6 straight-up & 6-9 spread
Season: 111-53 (68%) straight-up & 89-75 (54%) spread
Winners are in bold. Pick against the spread selection is listed to the side.
Week 12
Thursday, Nov. 20, 2025
8:15pm
Buffalo (-4.5) at Houston – Houston +4.5
Sunday, Nov. 23, 2025
1pm
NY Jets at Baltimore (-13.5) – Baltimore -13.5
Pittsburgh at Chicago (-3) – Chicago -3
New England (-7.5) at Cincinnati – New England -7.5
NY Giants at Detroit (-13.5) – Detroit -13.5
Minnesota at Green Bay (-6.5) – Minnesota +6.5
Indianapolis at Kansas City (-3.5) – Kansas City -3.5
Seattle (-12.5) at Tennessee – Seattle -12.5
4:05/4:25pm
Jacksonville (-2.5) at Arizona – Jacksonville -2.5
Cleveland at Las Vegas (-3.5) – Las Vegas -3.5
Philadelphia (-3) at Dallas – Dallas -3
Atlanta at New Orleans (-1.5) – New Orleans -1.5
8:20pm
Tampa Bay at LA Rams (-7) – LA Rams -7
Monday, Nov. 24, 2025
8:15pm
Carolina at San Francisco (-7.5) – San Francisco -7.5
Off This Week: Denver, LA Chargers, Miami, Washington
NEW YORK — Nov. 18, 2025 — Sunday of Week 11 was one of the most competitive, exciting days in NFL history as five teams recorded a game-winning score on the final play– Carolina, Chicago, Denver, Houston, and Miami – tied for the most on a single day all-time (Week 10, 2023; Week 4, 2018). There have been 43 games with a game-winning score in the final two minutes of regulation or in overtime this season, the most-ever through Week 11.
Week 12 is set to feature five games between teams that have a .500-or-better record, including two games, Pittsburgh at Chicago and Tampa Bay at the Los Angeles Rams, between division-leading teams. Of the five teams with at least eight wins this season, three – Indianapolis, New England and Philadelphia – are on the road.
For Week 12 capsules, click here.
Here’s a look at a few interesting storylines entering Week 12:
- Indianapolis (8-2) at Kansas City (5-5) (Sunday, 1 p.m. ET, CBS): The Colts lead the NFL with 32.1 points per game and 396.9 total yards of offense per game, paced by the league’s leading passer, quarterback Daniel Jones (265.9 passing yards per game) and leading rusher, running back Jonathan Taylor (113.9 rushing yards per game).
- In Week 10 in Berlin, Taylor set a franchise record with 286 scrimmage yards (244 rushing, 42 receiving) and became the fourth player in NFL history with three touchdowns in five games within a single season, joining Pro Football Hall of Famers LaDainian Tomlinson (six games in 2006) and Marshall Faulk (five in 2000) as well as Chuck Foreman (five in 1975).
- Taylor, who had 20 scrimmage touchdowns in 2021, leads the NFL with 17 scrimmage touchdowns and with three more touchdowns this season, can become the sixth player ever with at least 20 scrimmage touchdowns in multiple seasons, joining Pro Football Hall of Famers Marshall Faulk, Emmitt Smith and LaDainian Tomlinson as well as Shaun Alexander and Priest Holmes.
- Kansas City quarterback Patrick Mahomes has 40,791 career passing yards, including the playoffs, and can surpass Pro Football Hall of Famer Peyton Manning (41,082) for the most passing yards, including the postseason, by a player in his first nine seasons in NFL history.
- Mahomes has 1,112 passing yards (278 per game) and 13 touchdown passes for a 121.9 rating in his past four at home, with at least 250 passing yards and three touchdown passes in each game. Only three players all-time –Steve Beuerlein (1999 with Carolina), Drew Brees (2015 with New Orleans) and Aaron Rodgers (2011 with Green Bay) – have at least 250 passing yards and three touchdown passes in five consecutive home games within a single season.
- New England (9-2) at Cincinnati (3-7) (Sunday, 1 p.m. ET, CBS): The Patriots enter Week 12 having won eight consecutive games, tied with Denver (on a bye this week) for the longest active winning streak in the NFL. New England is 5-0 on the road this season, the only team with an undefeated road record in 2025.
- New England can become the second team in NFL history to win nine consecutive games with at least 23 points scored and 23-or-less points allowed in each game, joining the 1961 Houston Oilers.
- Patriots quarterback Drake Maye, who leads the NFL with 2,836 passing yards and ranks second among qualified passers with a 113.2 rating, can become the third quarterback under the age of 24 with at least 10 games of 200-or-more passing yards and a passer rating of 100-or-higher in NFL history, joining Patrick Mahomes (13 games in 2018) and Matthew Stafford (10 games in 2011).
- New England rookie running back TreVeyon Henderson, who had two rushing touchdowns in Week 10 and three touchdowns (two rushing, one receiving) in Week 11, can become the third rookie in the Super Bowl era with multiple rushing touchdowns in three consecutive games, joining Mike Anderson (2000 with Denver) and Pro Football Hall of Famer Curtis Martin (1995 with New England).
- Philadelphia (8-2) at Dallas (4-5-1) (4:25 p.m. ET, FOX): The Eagles defeated the Cowboys, 24-20, to open the 2025 season as quarterback Jalen Hurts rushed for two touchdowns in the victory. Philadelphia head coach Nick Sirianni has 56 regular-season wins since being hired by the team in 2021 and with a win, can tie Pro Football Hall of Famer Paul Brown (57) for the second-most regular-season wins by a head coach in his first five seasons all-time, trailing only George Seifert (62).
- Hurts, who has 16 touchdown passes this season, is one of six quarterbacks all-time with at least 250 pass attempts and only one interception in his team’s first 10 games of a season, joining Drew Brees (2018 with New Orleans), Justin Herbert (2024 the L.A. Chargers), Bernie Kosar (1991 with Cleveland), Patrick Mahomes (2019 with Kansas City) and Aaron Rodgers (2018 with Green Bay).
- Dallas quarterback Dak Prescott recorded four touchdown passes and a season-high 138.6 rating in Week 11. Since entering the NFL in 2016, he is one of three with at least three touchdown passes in 40-or-more games (41), joining Patrick Mahomes (46 games) and Aaron Rodgers (41).
- Tampa Bay (6-4) at the Los Angeles Rams (8-2) (8:20 p.m. ET, NBC): The Rams have won five consecutive games, the longest active win streak in the NFC, and rank second in the NFL in scoring defense (17.2 points per game allowed) entering Week 12
- Los Angeles Rams quarterback Matthew Stafford leads the NFL with 27 touchdown passes this season and can become the first since Tom Brady (2021 with Tampa Bay) with at least 30 touchdown passes in his team’s first 11 games of a season.
- Los Angeles Rams wide receiver Davante Adams recorded his 10th touchdown reception of the season, his 1,000th career reception, last week and became the fifth wide receiver in NFL history with at least 1,000 receptions in their first 12 seasons, joining Pro Football Hall of Famers Jerry Rice (1,050 receptions), Marvin Harrison (1,042) and Andre Johnson (1,012) as well as Larry Fitzgerald (1,018).
- Adams is one of five players in NFL history with at least 10 touchdown receptions in seven career seasons, joining Pro Football Hall of Famers Randy Moss (nine seasons), Jerry Rice (nine), Marvin Harrison (eight) and Terrell Owens (eight).
- Pittsburgh (6-4) at Chicago (7-3) (1 p.m. ET, CBS): The Steelers-Bears matchup is one of two, along with Buccaneers-Rams, in Week 12 between division-leading teams. Chicago leads the NFL in takeaways (22) and turnover differential (+16) this season, the fourth-highest turnover differential by a team in its first 10 games of a season in the past 20 years (2006-25).
- The Bears have won six of their past seven games, with five of the wins featuring the game-winning score in the final two minutes of the fourth quarter or overtime. Since 1970, only seven teams have had more wins with the game-winning score in the final two minutes of regulation or in overtime in a single season.
- Carolina (6-5) at San Francisco (7-4) (8:15 p.m. ET, ESPN): Carolina and San Francisco are two of the seven teams that missed the postseason in 2024 with a winning record this season.
- Last week, Panthers quarterback Bryce Young recorded a franchise-record 448 passing yards and rookie wide receiver Tetairoa McMillan became the sixth rookie since 2000 with at least eight receptions, 130 receiving yards and two touchdown receptions in a game, joining Odell Beckham Jr. (three times), Anquan Boldin, Ja’Marr Chase, Justin Jefferson and Roy Williams.
- San Francisco running back Christian McCaffrey leads the NFL with 1,439 scrimmage yards and ranks tied for second with 11 scrimmage touchdowns (six rushing, five receiving). He has four career seasons with at least five rushing touchdowns and five receiving touchdowns, surpassing Pro Football Hall of Famer Marshall Faulk (three seasons) for the most such seasons in NFL history.
- New York Jets (2-8) at Baltimore (5-5) (1 p.m. ET, CBS): The Ravens have won four consecutive games and are the fifth team in the past six seasons (2020-25) to reach a .500 record after beginning 1-5, joining the 2023 Denver Broncos, 2022 Detroit Lions, 2021 Miami Dolphins and 2020 Minnesota Vikings.
- Baltimore is one of five teams, along with Carolina, Chicago, Houston and Kansas City, with a .500-or-better entering Week 12 after beginning the season 0-2.
- Ravens quarterback Lamar Jackson has 26 TDs (25 passing, one rushing) and a 121.7 rating in his past 10 home starts, with at least two touchdown passes in each of his past seven at home. He can become the first quarterback since Drew Brees (2018) with at least three touchdown passes, no interceptions and a passer rating of 125-or-higher in three consecutive home starts.
- Baltimore running back Derrick Henry has a rushing touchdown in 83 career games, including the playoffs, tied with Pro Football Hall of Famer John Riggins (83 games) for the fifth-most games with a rushing touchdown, including the postseason, in NFL history. Only Pro Football Hall of Famers Emmitt Smith (130 games), Marcus Allen (100) and LaDainian Tomlinson (96), as well as Adrian Peterson (89) have more.
- JOSH ALLEN
- Buffalo quarterback Josh Allenpassed for 317 yards with three touchdowns and added three rushing touchdowns last week and is the only player in NFL history with at least 300 passing yards, three touchdown passes and three rushing touchdowns in a single game.
- Since entering the NFL in 2018, Allen has 33,383 combined passing and rushing yards (28,890 passing, 4,493 rushing) and 213 touchdown passes.
- With a touchdown pass on Thursday Night Footballat Houston (8:15 p.m. ET, Prime Video), Allen will surpass Pro Football Hall of Famer Brett Favre (213 touchdown passes) for the fifth-most touchdown passes by a player in his first eight seasons in NFL history, trailing only Patrick Mahomes (245 touchdown passes), Pro Football Hall of Famers Peyton Manning (244) and Dan Marino (241) as well as Russell Wilson (227).
- The players with the most touchdown passes in their first eight seasons in NFL history:
| PLAYER | TEAM | PASS TDs |
| Patrick Mahomes | Kansas City | 245 |
| Peyton Manning HOF | Indianapolis | 244 |
| Dan Marino HOF | Miami | 241 |
| Russell Wilson | Seattle | 227 |
| Josh Allen | Buffalo | 213* |
| Brett Favre HOF | Green Bay | 213 |
| *in eighth season | ||
- With 138 combined passing and rushing yards on Thursday, Allen can surpass Matt Ryan(33,520 combined yards) for the fourth-most combined passing and rushing yards in a player’s first eight seasons in NFL history. Only Patrick Mahomes (34,595 combined yards), Pro Football Hall of Famer Peyton Manning (33,854), and Russell Wilson (33,727) have more.
- The players with the most combined passing and rushing yards in their first eight seasons in NFL history:
| PLAYER | TEAM | COMBINED YARDS | PASS YARDS | RUSH YARDS |
| Patrick Mahomes | Kansas City | 34,595 | 32,352 | 2,243 |
| Peyton Manning HOF | Indianapolis | 33,854 | 33,189 | 665 |
| Russell Wilson | Seattle | 33,727 | 29,734 | 3,993 |
| Matt Ryan | Atlanta | 33,520 | 32,757 | 763 |
| Josh Allen* | Buffalo | 33,383 | 28,890 | 4,493 |
| *in eighth season | ||||
- Allen, who has 18 touchdown passes and 10 rushing touchdowns this season, has five consecutive seasons with at least 30 combined passing and rushing touchdowns and can surpass Pro Football Hall of Famer Brett Favre(five seasons) and Aaron Rodgers (five) for the second-most consecutive seasons with such in NFL history.
- The players with the most consecutive seasons with at least 30 combined passing and rushing touchdowns in NFL history:
| PLAYER | TEAM | SEASONS |
| Drew Brees | New Orleans | 9 (2008-16) |
| Josh Allen | Buffalo | 5* (2020-24) |
| Brett Favre HOF | Green Bay | 5 (1994-98) |
| Aaron Rodgers | Green Bay | 5 (2008-12) |
| *has 28 combined passing and rushing touchdowns in 2025 | ||
- With two touchdown passes on Thursday, Allen can become the first player in NFL history with at least 20 touchdown passes and 10 rushing touchdowns in three career seasons, surpassing Jalen Hurts(two seasons) and Cam Newton (two).
- With two rushing touchdowns in Week 12, Allen can surpass Philadelphia’s Jalen Hurts(16 career games) for the most career games with multiple rushing touchdowns by a quarterback all-time.
- Additionally, Allen can become the first quarterback in NFL history with at least two rushing touchdowns in five games within a single season, surpassing Jalen Hurts(four games in 2021 and 2023 with Philadelphia) and Cam Newton (four in 2020 with New England).
- MATTHEW STAFFORD
- Los Angeles Rams quarterback Matthew Staffordleads the NFL with 27 touchdown passes this season and has just two interceptions entering Week 12.
- On Sunday Night Footballagainst Tampa Bay (8:20 p.m. ET, NBC), Stafford can join Tom Brady, Patrick Mahomes and Aaron Rodgers (three times) as the only players in NFL history with at least 30 touchdown passes and five-or-fewer interceptions in their team’s first 11 games of a season.
- The players with at least 30 touchdown passes and five-or-fewer interceptions in their team’s first 11 games of a season in NFL history:
| PLAYER | TEAM | SEASON | PASS TDs | INTs |
| Tom Brady MVP | New England | 2007 | 39 | 4 |
| Patrick Mahomes | Kansas City | 2020 | 30 | 2 |
| Aaron Rodgers MVP | Green Bay | 2020 | 33 | 4 |
| Aaron Rodgers MVP | Green Bay | 2014 | 30 | 3 |
| Aaron Rodgers MVP | Green Bay | 2011 | 33 | 4 |
| Matthew Stafford | L.A. Rams | 2025 | 27* | 2* |
| *in team’s first 10 games | ||||
- DAK PRESCOTT
- Dallas quarterback Dak Prescott passed for 268 yards and four touchdowns last week, his 41st career game with at least three touchdown passes since entering the NFL in 2016.
- With three touchdown passes on Sunday against Philadelphia (4:25 p.m. ET, FOX), Prescott will surpass Russell Wilson(41 games) for the fifth-most games with at least three touchdown passes by a player in their first 10 seasons in NFL history.
- The players with the most games with at least three touchdown passes in their first 10 seasons in NFL history:
| PLAYER | TEAM | GAMES |
| Peyton Manning HOF | Indianapolis | 48 |
| Dan Marino HOF | Miami | 48 |
| Patrick Mahomes | Kansas City | 46^ |
| Aaron Rodgers | Green Bay | 43 |
| Dak Prescott | Dallas | 41* |
| Russell Wilson | Seattle | 41 |
| *in 10th season; ^in ninth season | ||
- JONATHAN TAYLOR
- Indianapolis running back Jonathan Taylor recorded a career-high and franchise-record 286 scrimmage yards (244 rushing, 42 receiving) and three rushing touchdowns in Berlin in Week 10 and became the only player in NFL history to record four games with at least three rushing touchdowns through the first 10 weeks of a season.
- Taylor has 73 scrimmage touchdowns (66 rushing, seven receiving) in 77 career games and on Sunday at Kansas City (1:00 p.m. ET, CBS), can become the fifth running back in NFL history to reach 75 scrimmage touchdowns in fewer than 80 games, joining Pro Football Hall of Famers Jim Brown(72 games), LaDainian Tomlinson (72) and Emmitt Smith (77) as well as Todd Gurley (78).
- The fastest players to reach 75 career scrimmage touchdowns in NFL history:
| PLAYER | TEAM | GAMES |
| Jim Brown HOF | Cleveland | 72 |
| LaDainian Tomlinson HOF | San Diego Chargers | 72 |
| Emmitt Smith HOF | Dallas | 77 |
| Todd Gurley | St. Louis Rams | 78 |
| Lance Alworth HOF | San Diego Chargers | 80 |
| Jonathan Taylor | Indianapolis | 77* |
| *has 73 scrimmage touchdowns | ||
- With a rushing touchdown on Sunday, Taylor, who turns 27 years old following the 2025 regular-season, can tie Todd Gurley(67 rushing touchdowns) for the fourth-most rushing touchdowns by a player under the age of 27 in NFL history. Only Pro Football Hall of Famers Emmitt Smith (96 rushing touchdowns), LaDainian Tomlinson (72), and Jim Brown (70) have more.
- The most rushing touchdowns by a player under the age of 27 in NFL history:
| PLAYER | TEAM | RUSH TDs |
| Emmitt Smith HOF | Dallas | 96 |
| LaDainian Tomlinson HOF | San Diego Chargers | 72 |
| Jim Brown HOF | Cleveland | 70 |
| Todd Gurley | St. Louis Rams | 67 |
| Jonathan Taylor | Indianapolis | 66* |
| *turns 27 on Jan. 19, 2026 | ||
- DERRICK HENRY
- Baltimore running back Derrick Henry rushed for 103 yards and a touchdown last week, tying Pro Football Hall of Famer John Riggins(83 games) for the fifth-most games with a rushing touchdown, including the postseason, in NFL history. It marked his 42nd career game, including the playoffs, with at least 100 rushing yards and a rushing touchdown.
- On Sunday against the New York Jets (1:00 p.m. ET, CBS), Henry can tie Pro Football Hall of Famer Barry Sanders(43 games) for the fourth-most games with at least 100 rushing yards and a rushing touchdown, including the postseason, in NFL history. Only Pro Football Hall of Famers Emmitt Smith (63 games), Walter Payton (48) and LaDainian Tomlinson (44) have more.
- The players with the most games with at least 100 rushing yards and a rushing touchdown, including the postseason, in NFL history:
| PLAYER | TEAM(S) | GAMES |
| Emmitt Smith HOF | Dallas, Arizona | 63 |
| Walter Payton HOF | Chicago | 48 |
| LaDainian Tomlinson HOF | San Diego Chargers, N.Y. Jets | 44 |
| Barry Sanders HOF | Detroit | 43 |
| Derrick Henry | Tennessee, Baltimore | 42 |
- BIJAN ROBINSON
- Atlanta running back Bijan Robinson had 143 scrimmage yards (104 rushing yards, 39 receiving) and two rushing touchdowns last week and leads the league in scrimmage yards (4,639) since entering the NFL in 2023.
- On Sunday at New Orleans (4:25 p.m. ET, FOX), Robinson – who has 47 receptions and 1,289 scrimmage yards this season – can become the fifth player in NFL history with at least 50 receptions and 1,400 scrimmage yards in each of his first three career seasons, joining Matt Forte, Justin Jefferson, Pro Football Hall of Famer LaDainian Tomlinsonand Herschel Walker.
- Robinson, who turns 24 years old following the 2025 regular-season, has 24 career games with at least 100 scrimmage yards and can become the sixth running back under the age of 24 all-time with at least 25 games with 100-or-more scrimmage yards, joining Pro Football Hall of Famers Edgerrin James(32 games) and Emmitt Smith (25) as well as Ezekiel Elliott (29), Clinton Portis (28) and Christian McCaffrey (25).
- The running backs under the age of 24 with the most games with at least 100 scrimmage yards in NFL history:
| PLAYER | TEAM | GAMES |
| Edgerrin James HOF | Indianapolis | 32 |
| Ezekiel Elliott | Dallas | 29 |
| Clinton Portis | Denver | 28 |
| Christian McCaffrey | Carolina | 25 |
| Emmitt Smith HOF | Dallas | 25 |
| Bijan Robinson | Atlanta | 24* |
| Barry Sanders HOF | Detroit | 24 |
| *turns 24 on Jan. 30, 2026 | ||
- JAXON SMITH-NJIGBA
- Seattle wide receiver Jaxon Smith-Njigba had nine catches for 105 yards last week and became the first player in NFL history to record at least 75 receiving yards in each of their first 10 games of a season.
- With at least 75 receiving yards on Sunday at Tennessee (1:00 p.m. ET, FOX), Smith-Njigba can join Pro Football Hall of Famer Marvin Harrison(14 games) and Cooper Kupp (13) as the only players with at least 11 consecutive games of 75+ receiving yards in a single season in NFL history.
- The players with the most consecutive games with at least 75 receiving yards in a single season in NFL history:
| PLAYER | TEAM | SEASON | GAMES |
| Marvin Harrison HOF | Indianapolis | 2002 | 14 |
| Cooper Kupp | L.A. Rams | 2021 | 13 |
| David Boston | Arizona | 2001 | 10 |
| Elroy Hirsch | L.A. Rams | 1951 | 10 |
| Jaxon Smith-Njigba | Seattle | 2025 | 10* |
| *active streak | |||
- TREY MCBRIDE
- Arizona tight end Trey McBride recorded 10 receptions for 115 yards and a touchdown last week, his fifth-consecutive game with a touchdown reception, and became the third tight end in NFL history with at least five receptions in 12-or-more consecutive games, joining Travis Kelce(15 consecutive games in 2018) and Pro Football Hall of Famer Tony Gonzalez (13 in 2008-09).
- With a touchdown reception on Sunday against Jacksonville (4:05 p.m. ET, CBS), McBride can become the third tight end in NFL history with a touchdown reception in six consecutive games within a single season, joining Mark Andrews(2024 with Baltimore) and Rob Gronkowski (2011 with New England).
- McBride has 292 receptions since entering the NFL in 2021 and on Sunday, can surpass Jimmy Graham(301 receptions) for the most receptions by a tight end in his first four seasons in NFL history.
- McBride, who has 71 receptions and 718 receiving yards this season, can become the sixth tight end in NFL history with at least 80 receptions and 800 receiving yards in three consecutive seasons,joining Pro Football Hall of Famer Tony Gonzalez (three seasons) and trailing only Travis Kelce (nine), Todd Christensen (four), Jimmy Graham (four), Jason Witten (four).
- The tight ends with at least 80 receptions and 800 receiving yards in the most consecutive seasons in NFL history:
| PLAYER | TEAM | SEASONS |
| Travis Kelce | Kansas City | 9* (2016-24) |
| Todd Christensen | L.A. Raiders | 4 (1983-86) |
| Jimmy Graham | New Orleans | 4 (2011-14) |
| Jason Witten | Dallas | 4 (2007-10) |
| Tony Gonzalez HOF | Kansas City | 3 (2011-13) |
| Tony Gonzalez HOF | Kansas City | 3 (2007-09) |
| Trey McBride | Arizona | 2* (2023-24) |
| *has 71 receptions and 718 receiving yards in 2025 | ||
- MYLES GARRETT
- Defensive end Myles Garrett recorded four sacks last week and has a league-high 15 sacks this season. He ranks first in the NFL with 117.5 sacks since entering the league in 2017 and is the first player since 1982, when the individual sack became an official statistic, with at least 12 sacks in six consecutive seasons.
- With two sacks on Sunday at Las Vegas (4:05 p.m. ET, CBS), Garrett can join Pro Football Hall of Famer Reggie White(19 sacks) and Mark Gastineau (17.5) as the only players since 1982, when the individual sack became an official statistic, with at least 17 sacks through their first 11 games of a season.
- The players with the most sacks in their first 11 games of a season since 1982:
| PLAYER | TEAM | SEASON | SACKS |
| Reggie White HOF | Philadelphia | 1987 | 19.0 |
| Mark Gastineau | N.Y. Jets | 1984 | 17.5 |
| Aldon Smith | San Francisco | 2012 | 16.5 |
| Lawrence Taylor HOF | N.Y. Giants | 1986 | 16.5 |
| Myles Garrett | Cleveland | 2025 | 15.0* |
| *in first 10 games | |||
- Garrett, who had 16 sacks in 2021 and 2022, can become the third player since 1982, when the individual sack became an official statistic, with at least 16 sacks in three career seasons, joining J. Watt(four seasons) and Pro Football Hall of Famer Reggie White (four).
- With at least one tackle for loss in Week 12, Garrett can join Von Miller (2012 with Denver) and J. Watt(2012 and 2015 with Houston) as the only players since 2000 with at least 23 tackles for loss in their team’s first 11 games of a season.
- The players with the most tackles for loss in their team’s first 11 games of a season since 2000:
| PLAYER | TEAM | SEASON | TFL |
| Von Miller | Denver | 2012 | 24 |
| J.J. Watt DPOY | Houston | 2012 | 24 |
| J.J. Watt DPOY | Houston | 2015 | 23 |
| Myles Garrett | Cleveland | 2025 | 22* |
| *in first 10 games | |||
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