Mayfield completed 25 of 33 passes for 334 yards and four scores for a near-perfect passer rating of 147.0. All four touchdowns occurred in the first half, matching Graham’s feat that was originally accomplished in 1951.
However, Peoples-Jones made up for it in the second quarter. On the Browns’ first play after Tennessee got on the board with Ryan Tannehill’s 17-yard touchdown pass to Corey Davis, Peoples-Jones burned Breon Borders with an out-and-up. Mayfield hit Peoples-Jones in stride for a 75-yard score and a 24-7 advantage with 13:04 left in the first half.
The Titans (8-4) tried to rally in the third quarter. They drew within 38-21 on two touchdowns by MyCole Pruitt. He caught a 22-yard pass from Tannehill, then recovered a fumble by A.J. Brown at the 3 and dove into the end zone.
Tannehill finished 29 of 45 for 389 yards with three touchdowns and the pick. He hit Cameron Batson with a 8-yard scoring strike with 28 seconds left to pull Tennessee within six points, but Andy Janovich fell on an onside kick to seal it.
League rushing leader Derrick Henry was held to 60 yards on 15 carries for Tennessee.
The Titans fell into a first place tie in the AFC South with Indianapolis, a 26-20 winner in Houston.