Moves with VFLs on Practice Squads; 6 Division games plus Brady Bowl in Week 10 in the NFL with predictions

Here are my Week 10 NFL Game Predictions, both straight-up and against the spread and my results from last week and the season.

You’ll also find an array of fantastic notes down below for Week 10 and the 2025 season courtesy of NFL Communications press releases.

There are 24 VFLs on 53-player rosters in the NFL. There are 2 on practice squads and 4 more on injured reserve, bringing the league total to 30 with NFL teams. This week McCallan Castles was signed to the Packers practice squad and Hendon Hooker was released from the Panthers practice squad. See how each did in Week 9 here. Look for a VFL in the NFL, ex-Vol and local player update blog soon on this feed and website, 991TheSportsAnimal.com.

Vince’s Picks Results
Week 9: 10-4 straight-up & 9-5 spread
Season: 93-42 (69%) straight-up & 77-58 (57%) spread

Winners are in bold. Pick against the spread selection is listed to the side.

Week 10
Thursday, Nov. 6, 2025
8:15pm
Las Vegas at Denver (-9) – Las Vegas (+9)

Sunday, Nov. 9, 2025
9:30am
Atlanta vs. Indianapolis (-6.5) in Berlin – Indianapolis

1pm
NY Giants at Chicago (-4.5) – Chicago (-4.5)
New Orleans at Carolina (5.5) – New Orleans (+5.5)
Jacksonville (-1) at Houston – Jacksonville (-1)
Buffalo (-9.5) at Miami – Buffalo (-9.5)
Baltimore (-4) at Minnesota – Baltimore (-4)
Cleveland (-2) at NY Jets – Cleveland (-2)
New England at Tampa Bay (-2.5) – Tampa Bay (-2.5)

4:05/4:25pm
Arizona at Seattle (-6.5) – Seattle (-6.5)
LA Rams (-4.5) at San Francisco – San Francisco (+4.5)
Detroit (-8) at Washington – Detroit (-8)

8:20pm
Pittsburgh at LA Chargers (-3) – LA Chargers (-3)

Monday, Nov. 10, 2025
8:15pm
Philadelphia at Green Bay (-2.5) – Philadelphia (+2.5)

Off This Week: Cincinnati, Kansas City, Dallas, Tennessee

NEW YORK — Nov. 4, 2025 — As the 2025 season crosses the halfway point in Week 10, six of the eight divisions have a team in first place or tied for first that did not win its division last season. Denver (7-2), Indianapolis (7-2), and New England (7-2) are tied for the best record in the NFL while seven teams – Buffalo, the Los Angeles Chargers, the Los Angeles Rams, Philadelphia, San Francisco, Seattle and Tampa Bay – have six wins through Week 9.

For Week 10 capsules, click here.

Here’s a look at a few interesting storylines entering Week 10:

• Berlin bound: As part of the league’s commitment to playing regular-season games in Germany, the NFL will continue its international slate of games with the first-ever regular season game in Berlin in Week 10 as the Atlanta Falcons(3-5) meet the Indianapolis Colts (7-2) (Sunday, 9:30 a.m. ET, NFL Network) at the Olympic Stadium Berlin.
  • Indianapolis running back Jonathan Taylorranks second in the NFL with 1,113 scrimmage yards this season while Atlanta running back Bijan Robinson ranks third with 1,058 scrimmage yards. It will mark the first game since Week 10, 2002 (Pro Football Hall of Famers Marshall Faulk and LaDainian Tomlinson) to feature opposing players each with at least 1,000 scrimmage yards in Week 10 or earlier.
• Primetime in Week 10:Five of the six teams appearing in primetime this week (7 p.m. ET or later) have at least five wins, including four teams that currently sit in first place in their division.
  • Las Vegas (2-6) at Denver (7-2) (Thursday night, 8:15 p.m. ET, Prime Video): The Broncos have won six consecutive games since Week 4 and since Week 8 last season, have won nine consecutive home games. Denver leads the NFL with 40 sacks, becoming the 10th team ever with at least 40 sacks in its first nine games of a season and first since the 2000 Tampa Bay Buccaneers(41 sacks).
    • The Broncos +31-sack differential (40 sacks, nine sacks allowed) is the largest through a team’s first nine games of a season in NFL history, surpassing the 1990 Miami Dolphins(+29).
    • Denver quarterback Bo Nix, with at least two touchdown passes on Thursday night, can become the fourth quarterback ever with at least two touchdown passes in 10 home games within his first two career seasons, joining Justin Herbert(11 home games with multiple touchdown passes), Pro Football Hall of Famer Dan Marino (10) and Kyler Murray (10).
    • Las Vegas tight end Brock Bowerslast week became the sixth tight end all-time with at least 10 receptions, 125 receiving yards and three touchdowns in a game, joining Pro Football Hall of Famers Kellen Winslow Sr. (twice), Antonio Gates and Shannon Sharpe as well as Todd Christensen and Keith Jackson.
    • Bowers, who has 143 receptions in 22 career games, can become the fastest tight end and second fastest player to reach 150 career receptions in NFL history, surpassing Michael Thomas(24 games). Only Odell Beckham Jr. (21 games) reached the mark faster.
  • Pittsburgh (5-3) at the Los Angeles Chargers (6-3) (Sunday night, 8:20 p.m. ET, NBC): The Steelers are set to appear in their third primetime game in four weeks while the Chargers look to improve to 4-0 in primetime games this season.
    • Pittsburgh quarterback Aaron Rodgersis tied for third in the NFL with 17 touchdown passes this season and is one of four quarterbacks with a passer rating of 95-or-higher in at least seven games. Rodgers has 166 career touchdown passes in primetime, the most all-time.
    • Rodgers, with two touchdown passes, can surpass Pro Football Hall of Famer Peyton Manning(165 games) for the third-most games with multiple touchdown passes in NFL history. Only Tom Brady (204 games) and Drew Brees (173) have more.
    • Los Angeles Chargers quarterback Justin Herbertranks second in the NFL in both passing yards (2,390) and touchdown passes (18). Last week, he recorded his 50th career game with multiple touchdown passes, one of five quarterbacks all-time with 50 such games in their first six career seasons.
  • Philadelphia (6-2) at Green Bay (5-2-1) (Monday night, 8:15 p.m. ET, ESPN/ABC): Last season, Philadelphia defeated Green Bay, 34-29, in São Paulo in Week 1 and 22-10, in Philadelphia in the 2024 NFC Wild Card round.
    • Prior to the team’s Week 9 bye, Philadelphia quarterback Jalen Hurtshad three touchdown passes with a 158.3 passer rating – the highest attainable mark – in Week 7 and four touchdown passes, including his 100th regular-season touchdown pass, with a 141.5 passer rating in Week 8. Only Aaron Rodgers (2011) and Pro Football Hall of Famer Kurt Warner (1999) have recorded three-or-more touchdown passes and a passer rating of 140-or-higher in three consecutive games.
    • Since entering the NFL in 2019, Green Bay running back Josh Jacobshas 71 career rushing touchdowns in 98 career games, second-most in the NFL during that span. He has at least one rushing touchdown in 49 career games and with a rushing touchdown in his next two games, can become the sixth player since 2000 with a rushing touchdown in 50 of his first 100 career games, joining Pro Football Hall of Famer LaDainian Tomlinson (64 games), Adrian Peterson (60), Shaun Alexander (58), Ezekiel Elliott (52) and Derrick Henry (50).
  • Matchups of five-plus win teams: There are four matchups in Week 10 – New England at Tampa Bay on Sunday, the Los Angeles Rams at San Francisco on Sunday, Pittsburgh at the Los Angeles Chargers on Sunday night and Philadelphia at Green Bay on Monday night – between teams each with at least five wins this season. It marks the first time since Week 9, 2020 that there were four such games in Week 10 or earlier of a season.
    • New England (7-2) at Tampa Bay (6-2) (Sunday, 1 p.m. ET, CBS): The Patriots, tied with the Broncos and Colts for the best record in the AFC, and the Buccaneers, tied with the Eagles and Seahawks for the best record in the NFC, will mark the first time since Week 16, 2023 (Baltimore vs. San Francisco) that the teams with the best record or tied for the best record in each conference will meet.
      • New England quarterback Drake Mayebecame the first player under the age of 24 and fourth player in NFL history to record at least 200 passing yards and a passer rating of 100-or-higher in eight consecutive games, joining Aaron Rodgers (12 consecutive games in 2011 and eight in 2020), Tom Brady (eight in 2007) and Pro Football Hall of Famer Peyton Manning (eight in 2004).
      • In Week 8, Tampa Bay safety Antoine Winfield Jr. recorded his first two takeaways (one interception, one fumble recovery) of the season and since entering the NFL in 2020, is one of two, along with Pittsburgh linebacker J. Watt, with 10 fumble recoveries.
    • Los Angeles Rams (6-2) at San Francisco (6-3) (Sunday, 4:25 p.m. ET, FOX): On Thursday Night Footballin Week 5, the 49ers defeated the Rams, 26-23, in overtime as running back Christian McCaffrey recorded eight receptions, 139 scrimmage yards (82 receiving, 57 rushing) and a touchdown reception in the win.
      • McCaffrey leads the NFL with 1,222 scrimmage yards (626 receiving, 596 rushing) in 2025, including a league-leading eight games with at least 100 scrimmage yards. Last week, he recorded his 33rd career touchdown reception, second-most among running backs in the Super Bowl era and had his 16th career game with both a rushing touchdown and receiving touchdown, surpassing Pro Football Hall of Famer Marshall Faulk(15 games) for the most such games in NFL history.
      • Los Angeles Rams quarterback Matthew Staffordleads the NFL with 21 touchdown passes this season, including nine in his past two games, and became the fourth quarterback ever with at least 20 touchdown passes and two-or-fewer interceptions (two) in his first eight games of a season, joining Tom Brady (2007 and 2015), Patrick Mahomes (2020) and Aaron Rodgers (2020).
      • Stafford enters Week 10 with 398 career regular-season touchdown passes and can become the ninth quarterback all-time with 400 career regular-season touchdown passes.
      • Rams wide receiver Davante Adamsleads the NFL with eight touchdown receptions this season, including five in his past two games, and became the fifth wide receiver in the Super Bowl era with at least eight touchdown receptions in six consecutive seasons, joining Pro Football Hall of Famers Jerry Rice (11 from 1986-96), Marvin Harrison (eight from 1999-2006) and Cris Carter (six from 1995-2000) as well as Antonio Brown (six from 2013-18).
      • Adams enters Week 10 with 111 career regular-season touchdown receptions, tied with Pro Football Hall of Famer Tony Gonzalez(111) for the eighth-most regular-season touchdown receptions in NFL history.
    • Six wins in the NFC West: Three teams – the Los Angeles Rams(6-2), San Francisco (6-3) and Seattle (6-2) – each have six wins this season, marking the sixth time since 2002 that a division has had three teams with at least six wins through the first nine weeks of a season. The previous occurrences: 2024 NFC North, 2022 AFC East and NFC East, 2016 AFC West and 2011 AFC North.
      • Arizona (3-5) at Seattle (6-2) (Sunday, 4:05 p.m. ET, CBS): In Week 4 on Thursday Night Football, Seattle defeated Arizona, 23-20, as kicker Jason Myerskicked a game-winning 52-yard field goal as time expired. The Seahawks are one of two NFC teams, along with the Rams, to allow fewer than 20 points per game this season (18.8) and are one of two teams in the NFL, along with Houston, to allow 20-or-fewer points in seven games in 2025.
        • Seattle wide receiver Jaxon Smith-Njigbaleads the NFL with 948 receiving yards and surpassed Pro Football Hall of Famer Isaac Bruce (938 receiving yards in 1995) for the most receiving yards by a player under the age of 25 in his team’s first eight games of a season in NFL history.
        • Smith-Njigba leads the NFL with six games of 100-or-more receiving yards, including each of his past four, and can become the fifth player all-time with at least eight receptions and 100 receiving yards in five consecutive games, joining Pro Football Hall of Famers Isaac Bruce(six consecutive games in 1995) and Calvin Johnson (five in 2012) as well as Anquan Boldin (five in 2005) and Michael Thomas (five in 2019).
        • Arizona tight end Trey McBridehas at least five receptions in 10 consecutive games and became the third tight end in NFL history with at least five receptions in 10 consecutive games, joining Travis Kelce (15 consecutive games in 2018 and 11 from 2020-21) and Pro Football Hall of Famer Tony Gonzalez (13 from 2008-09).
        • Cardinals defensive lineman Calais Campbellhad two sacks in Week 9 and has five sacks this season, joining Pro Football Hall of Famers Bruce Smith (18 seasons), Julius Peppers (16) and Reggie White (15) as the only players since 1982, when the individual sack became an official statistic, with at least five sacks in 15-or-more career seasons.
      • Buffalo (6-2) at Miami (2-7) (Sunday, 1 p.m. ET, CBS): In Week 3 on Thursday Night Football, Buffalo defeated Miami, 31-21, as quarterback Josh Allenhad three touchdown passes, including the go-ahead touchdown pass with 7:17 remaining in the fourth quarter. Allen is 13-2 in 15 career starts against the Dolphins, with 45 touchdowns (40 passing, five rushing) and a 110.3 passer rating.
        • Allen has 79 career rushing touchdowns, including the postseason, and with his two rushing touchdowns last week, surpassed Cam Newton(77 rushing touchdowns) for the most rushing touchdowns by a quarterback, including the playoffs, in NFL history.
        • Allen, who has seven rushing touchdowns this season, became the first quarterback and sixth player ever with at least six rushing touchdowns in eight consecutive seasons, joining Pro Football Hall of Famers Marshall Faulk(10 consecutive seasons from 1994-2004), LaDainian Tomlinson (10 from 2001-10), Jim Brown (nine from 1957-65) and Thurman Thomas (eight from 1989-96) as well as Derrick Henry (eight from 2018-25).
        • Buffalo head coach Sean McDermotthas 99 wins (92 regular season, seven postseason) since he was hired in 2017 and with his next victory, can become the sixth head coach ever with at least 100 wins in his first nine seasons, joining George Seifert (116 wins), Pro Football Hall of Famers Paul Brown (104), John Madden (103) and Joe Gibbs (102) as well as Mike McCarthy (101).

LAMAR JACKSON

Baltimore quarterback Lamar Jackson, in his first 99 career starts, has 21,045 passing yards, 6,214 rushing yards and 212 touchdowns (179 passing, 33 rushing) along with a 103.5 passer rating.

Jackson, with a win in his 100th career start at Minnesota on Sunday (1 p.m. ET, FOX), can surpass Pro Football Hall of Famer Ken Stabler (72 wins) for the fourth-most wins by a quarterback in their first 100 career starts in NFL history. Only Patrick Mahomes (78 wins), Tom Brady (76) and Pro Football Hall of Famer Roger Staubach (76) have more.

Jackson can become the third quarterback all-time with a passer rating of 100-or-higher in his first 100 career starts, joining Aaron Rodgers (107.3 passer rating) and Patrick Mahomes (103.0).

The quarterbacks with the highest passer rating in their first 100 career starts in NFL history:

DRAKE MAYE

New England quarterback Drake Maye passed for 259 yards and two touchdowns with a 102.5 passer rating last week, and became the first player under the age of 24 and fourth in NFL history to record at least 200 passing yards and a passer rating of 100-or-higher in eight consecutive games.

With at least 200 passing yards and a passer rating of 100-or-higher on Sunday at Tampa Bay (1 p.m. ET, CBS), Maye can become the second player in NFL history to record at least 200 passing yards and a passer rating of 100-or-higher in nine consecutive games, joining Aaron Rodgers (12 consecutive games in 2011).

In Week 10, Maye – who has no interceptions and a passer rating of 100-or-higher in each of his first four road starts this season – can become the sixth player in NFL history with zero interceptions and a passer rating of 100-or-higher in five consecutive road games in a single season, joining Tom Brady (2020 with Tampa Bay), Kirk Cousins (2021 with Minnesota), Nick Foles (2013 with Philadelphia), Carson Palmer (2005 with Cincinnati) and Tony Romo (2014 with Dallas).

The quarterbacks with zero interceptions and a passer rating of 100-or-higher in five consecutive road games within a single season in NFL history:

JUSTIN HERBERT

Los Angeles Chargers quarterback Justin Herbert totaled three touchdowns (two passing, one rushing) last week, his 50th-career game with multiple touchdown passes.

With at least two touchdown passes on Sunday Night Football against Pittsburgh (8:20 p.m. ET, NBC), Herbert can surpass Pro Football Hall of Famer Peyton Manning (50 games) for the fourth-most games with at least two touchdown passes by a player in his first six seasons in NFL history.

The players with the most games with at least two touchdown passes in their first six seasons in NFL history:

AARON RODGERS

Pittsburgh quarterback Aaron Rodgers is tied for third in the NFL with 17 touchdown passes this season, including five games with multiple touchdown passes.

With two touchdown passes on Sunday Night Football against the Los Angeles Chargers (8:20 p.m. ET, NBC), Rodgers can surpass Pro Football Hall of Famer Peyton Manning (165 games) for the third-most games with multiple touchdown passes in NFL history. Only Tom Brady (204 games) and Drew Brees (173) have more.

The players with the most games with at least two touchdown passes in NFL history:

JAXON SMITH-NJIGBA

Seattle wide receiver Jaxon Smith-Njigba led the Seahawks with eight receptions and 129 receiving yards last week, his fourth consecutive and sixth game overall this season with at least 100 receiving yards, the most in the NFL.

On Sunday against Arizona (4:05 p.m. ET, CBS), Smith-Njigba can become the first player in NFL history with at least eight receptions and 120 receiving yards in five consecutive games.

In Week 10, Smith-Njigba can join Antonio Brown (2014 with Pittsburgh) and Pro Football Hall of Famer Michael Irvin (1995 with Dallas) as the only players with at least 75 receiving yards in each of his first nine games of a season in NFL history.

At 23 years old, he leads the NFL with 948 receiving yards this season, the most through a team’s first eight games of a season by a player under the age of 25 in NFL history. This week, Smith-Njigba can move into the top-five for the most receiving yards by a player in his team’s first nine games of a season in the Super Bowl era.

The players with the most receiving yards in their team’s first nine games of a season in the Super Bowl era:

CHRISTIAN MCCAFFREY

San Francisco running back Christian McCaffrey had 173 scrimmage yards (106 rushing, 67 receiving) and two touchdowns (one rushing, one receiving) last week, his 16th career game with both a rushing touchdown and touchdown reception, surpassing Pro Football Hall of Famer Marshall Faulk (15 games) for the most such games in NFL history.

McCaffrey has eight scrimmage touchdowns (four rushing, four receiving) this season and on Sunday against the Los Angeles Rams (4:25 p.m. ET, FOX), can become the first player in NFL history with at least five rushing touchdowns and five receiving touchdowns in four career seasons, surpassing Pro Football Hall of Famer Marshall Faulk (three seasons).

McCaffrey – who enters Week 10 with 596 rushing yards and 626 receiving yards – can become the third player in NFL history with at least 600 rushing yards and 600 receiving yards in four career seasons, joining Pro Football Hall of Famer Marshall Faulk and Brian Westbrook.

Additionally, McCaffrey can join Timmy Brown (1965), Roger Craig (1985) and Pro Football Hall of Famer Marshall Faulk (1998) as the only players with at least 600 rushing yards and 600 receiving yards in his team’s first 10 games of a season in NFL history.

MYLES GARRETT

Cleveland defensive end Myles Garrett ranks second in the NFL with 10 sacks this season and became the third player since 1982, when the individual sack became an official statistic, with at least 10 sacks in eight consecutive seasons, joining Pro Football Hall of Famers Reggie White (nine from 1985-93) and John Randle (eight from 1992-99).

With two sacks on Sunday at the New York Jets (1:00 p.m. ET, CBS), Garrett can become the first player since 1982, when the individual sack became an official statistic, with at least 12 sacks in six consecutive seasons, surpassing Pro Football Hall of Famer Lawrence Taylor (five from 1985-89).

Additionally, Garrett can become the fifth player since 1982 with at least 12 sacks in seven career seasons, joining Pro Football Hall of Famers Reggie White (10 seasons), Kevin Greene (eight) and Bruce Smith (eight) as well as Leslie O’Neal (seven).

The players with the most seasons with at least 12 sacks since 1982:

DENVER BRONCOS

The Denver Broncos lead the NFL with 40 sacks, the most through a team’s first nine games of a season since Tampa Bay in 2000 (41 sacks).

On Thursday Night Football against Las Vegas (8:15 p.m. ET, Prime Video), the Broncos can surpass the 2000 New Orleans Saints (44 sacks) for the most sacks by a team in its first 10 games of a season since 1990.

The teams with the most sacks in their first 10 games of a season since 1990:

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