By the time the second top-10 game of the day kicked off at Death Valley, Arch Manning’s Heisman Trophy odds were on life support.

A pick, one touchdown and subpar numbers in general sent Manning’s odds to win the 2025 Heisman south rapidly.

The quarterbacks involved in the Saturday evening game in South Carolina, Clemson’s Cade Klubnik and LSU’s Garrett Nussmeier, were moved to co-favorites before either took a snap.

Their 15-2 odds (+700) on FanDuel were far superior to Manning’s, who went from 5-1 odds at kickoff of the noon ET game at Ohio State to +1800. Buckeyes wide receiver Jeremiah Smith, Georgia quarterback Gunner Stockton, South Carolina quarterback La’Norris Sellers and Oklahoma quarterback John Mateer all jumped to +1600 on Saturday.

Manning finished with pedestrian passing numbers in the No. 1 Longhorns’ 14-7 loss to the No. 3 Buckeyes. He completed 17 of 30 for 170 yards, one touchdown and an interception in the third quarter on a throw he would love to have back.

Penn State quarterback Drew Allar, Oregon quarterback Dante Moore and Miami quarterback Carson Beck were all +1800, even with Manning. The Hurricanes play Notre Dame on Sunday night.

Updated Heisman Trophy odds from FanDuel (Saturday, 7:45 p.m. ET):

Cade Klubnik (Clemson), +700

Garrett Nussmeier (LSU), +700

John Mateer (Oklahoma), +1600

LaNorris Sellers (South Carolina), +1600

Jeremiah Smith (Ohio State), +1600

Gunner Stockton (Georgia), +1600

Carson Beck (Miami), +1800

Dante Moore (Oregon), +1800

Drew Allar (Penn State), +1800

Arch Manning (Texas), +1800

Jackson Arnold (Auburn), +2000

Sam Leavitt (Arizona State), +2000

Julian Sayin (Ohio State), +2500

DJ Lagway (Florida), +2500

Jeremiyah Love (Notre Dame), +2500

Thomas Castellanos (Florida State), +3300

Marcel Reed (Texas A&M), +3500

Kevin Jennings (SMU), +3500

Austin Simmons (Ole Miss), +3500